| Autor: |
Nicoletto MO; Division of Medical Oncology, University Hospital, Padua, Italy., Fiorentino MV, Vinante O, Prosperi A, Tredese F, Tumolo S, Cima GP, Monfardini S |
| Jazyk: |
angličtina |
| Zdroj: |
Oncology [Oncology] 1992; Vol. 49 (6), pp. 467-73. |
| DOI: |
10.1159/000227094 |
| Abstrakt: |
Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal alpha 2a-Interferon. The usual single dosage was 54 x 10(6) U at weekly intervals for four times (eight times in responders): 10 histologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. alpha 2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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