Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide.

Autor: van der Veen RC; Department of Neurology, University of Southern California, Keck School of Medicine, MCA 245, 1333 San Pablo Street, Los Angeles, CA 90033, USA. vanderve@usc.edu, Dietlin TA, Hofman FM
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2003 Dec; Vol. 145 (1-2), pp. 86-90.
DOI: 10.1016/j.jneuroim.2003.09.012
Abstrakt: The cause of increased severity of experimental allergic encephalomyelitis (EAE) in inducible nitric oxide synthase (iNOS)(-/-) or IFN-gamma(-/-) mice remains unclear. Transient chimeras were generated to examine the source of iNOS-inducing IFN-gamma in the central nervous system (CNS). IFNgamma(-/-) donor cells induced severe EAE but no iNOS expression in the CNS of wild-type recipients upon their immunization. By contrast, milder EAE, but strong iNOS expression was induced in immunized recipients of wild-type donor spleen cells. These results demonstrate that IFN-gamma secretion by infiltrating spleen cells is essential for iNOS expression during CNS inflammation. Furthermore, splenic NO is immunosuppressive.
Databáze: MEDLINE
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