| Autor: |
Zaheer-ul-Haq; Department of Theoretical Chemistry, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. zaheer_qasmi@hotmail.com, Wellenzohn B, Tonmunphean S, Khalid A, Choudhary MI, Rode BM |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Dec 15; Vol. 13 (24), pp. 4375-80. |
| DOI: |
10.1016/j.bmcl.2003.09.034 |
| Abstrakt: |
We have derived a comprehensive structure-activity relationship (SAR) picture for a new series of natural acetylcholinesterase inhibitors isolated from Sarcococca saligna. A set of 32 previously isolated and tested pregnane-type steroidal alkaloids inhibitors were investigated with respect to their IC(50) values (pIC(50)) against the AChE enzyme in order to derive CoMFA models using atom-based alignment. A highly significant CoMFA model was obtained with r(2) value of 0.974. The q(2) (cross validation r(2)) value also confirms the statistical significance of our model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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