Elevated concentrations of soluble IL-2 receptor in both bronchoalveolar lavage fluid and serum in a patient with BOOP.

Autor: Matsuno O; Department of Internal Medicine, Usuki Cosmos Hospital, Usuki, Oita 875-0051, Japan. matsuno@oita-med.ac.jp, Okubo F, Masutomo K, Yoshida F, Okubo T, Miyazaki E, Kumamoto T
Jazyk: angličtina
Zdroj: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2003 Sep; Vol. 201 (1), pp. 61-5.
DOI: 10.1620/tjem.201.61
Abstrakt: Activated soluble IL-2 receptor (sIL-2R) levels are elevated in a variety of diseases associated with T-cell activation. There are no reports of sIL-2R elevations in broncholitis obliterans organizing pneumonia/cryptogenic organizing pneumonia (BOOP/COP), although activated T cells are increased in BOOP/COP. We present a patient with BOOP/COP with an elevated concentration of soluble IL-2 receptors in both serum and bronchoalveolar lavage fluid. Concomitant resolution of the high serum sIL-2R and the roentogenographic findings after steroid treatment suggested that serum sIL-2R levels increase in response to a localized lymphocytic inflammatory reaction in the lung.
Databáze: MEDLINE