[Influence of the indometafen radioprotector on the immune reactivity].

Autor: Mikhaĭlov PP; State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia., Mal'tsev VN, Shliakova TG, Khaustova LI, Romanova SV, Skachkova VG, Arsent'eva LG
Jazyk: ruština
Zdroj: Radiatsionnaia biologiia, radioecologiia [Radiats Biol Radioecol] 2003 Jul-Aug; Vol. 43 (4), pp. 428-31.
Abstrakt: In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.
Databáze: MEDLINE