| Autor: |
Paterson I; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk, Davies RD, Heimann AC, Marquez R, Meyer A |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2003 Nov 13; Vol. 5 (23), pp. 4477-80. |
| DOI: |
10.1021/ol0357853 |
| Abstrakt: |
[structure: see text] A highly stereocontrolled total synthesis of the cytotoxic macrolide (-)-callipeltoside A has been achieved in 23 steps (4.8% overall). Notable features include a novel asymmetric vinylogous aldol reaction to install the C13 stereocenter and (E)-trisubstituted alkene, an anti-selective aldol addition, a Sonogashira coupling, and, last, a Schmidt-type glycosylation to attach the sugar unit. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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