Inhibitors of the CDC25 phosphatases.

Autor: Prevost GP; Institut Henri Beaufour, Beaufour-Ipsen, 5 Avenue du Canada, Les Ulis 91966, France., Brezak MC, Goubin F, Mondesert O, Galcera MO, Quaranta M, Alby F, Lavergne O, Ducommun B
Jazyk: angličtina
Zdroj: Progress in cell cycle research [Prog Cell Cycle Res] 2003; Vol. 5, pp. 225-34.
Abstrakt: As essential cell cycle regulators, the CDC25 phosphatases are currently considered as potential targets for the development of novel therapeutic approaches. Here, we review the function and regulation of CDC25 phosphatases, their involvement in cancer and Alzheimer's disease, and the properties of several recently identified inhibitors.
Databáze: MEDLINE