| Autor: |
Magdalan J; Katedra i Zakład Farmakologii Akademii Medycznej we Wrocławiu, 50-345 Wrocław, ul. Mikulicza-Radeckiego 2., Kochman K, Smolarek M, Przewłocki M, Antończyk A |
| Jazyk: |
polština |
| Zdroj: |
Przeglad lekarski [Przegl Lek] 2003; Vol. 60 (4), pp. 268-70. |
| Abstrakt: |
The case of a 51-year-old man who ingested 100 mg of felodipine (Plendil, 20 tablets á 5 mg) and 9 g of theophylline (Theospirex retard, 30 tablets á 300 mg) is presented. The patient developed severe hypotension, tachycardia, circulatory insufficiency and paralytic ileus. No ECG effects were observed. Although felodipine led to a reduction in the bioability of theophylline, the serum theophylline concentration 15 h after the admission was 92 mg/L (the therapeutic concentration of theophylline 10-20 mg/L). The protracted hypotension did not respond to vasopressor and calcium therapy. The addition of 4-aminopyridine (4-AP) infusion resulted in fast receding of poisoning symptoms: increase of blood pressure, receding of circulatory insufficiency and metabolic acidosis, and return of peristalsis. This case suggests the usefulness of 4-AP in the treatment of poisoning by dihydropyridine derivatives. However, confirmation of the effectiveness of this substance for pharmacotherapy of dihydrophyridine derivatives poisoning requires further clinical research. The influence of 4-AP on calcium channels is indirect. It blocks potassium channels K1 in cytoplasm side which makes potassium stay inside the cell leading to depolarisation and opening of voltage-dependent calcium channels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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