[Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic].

Autor:	Starý J; II. dĕtská klinika 2. LF UK a FNM, Praha. jan.stary@lfmotol.cuni.cz, Gajdos P, Blazek B, Ptoszková H, Mihál V, Pospísilová D, Hrstková H, Dembická D, Kopecná L, Slavík Z, Hak J, Procházková D, Zahálka F, Cerná Z, Jabali Y, Timr P, Vávra V, Mydlil J, Hrusák O, Trka J
Jazyk:	čeština
Zdroj:	Casopis lekaru ceskych [Cas Lek Cesk] 2003; Vol. 142 (7), pp. 404-9.
Abstrakt:	Background: Prognosis of children with acute lymphoblastic leukaemia (ALL)--the most common cancer in childhood, has improved remarkably over the last 40 years. The authors report the treatment outcome in children with ALL cured according to ALL-BFM 90 Study protocol in the Czech Republic during the first half of nineties. Methods and Results: Children aged 0-18 years were included into the study in 10 centers between 1990 to 1996. Patients were classified into standard-risk (SR), medium-risk (MR) and high-risk (HR) group according to initial leukaemic burden, early treatment response, and genotype of leukaemia. Duration of the chemotherapy was two years. Treatment results were evaluated in 352 children. With a median follow-up of 7.3 years, event-free-survival (EFS) was 71.3% and overall survival 76.4%. EFS was 80.3%, 74% and 28.2% in SR, MR and HR group, respectively. Relapse was diagnosed in 17.8% of the patients. Conclusions: The treatment outcome of children with ALL improved significantly (p = 0.0045) compared to the previous study ALL-BFM 83 (EFS 62%). These results are comparable to those achieved by leading leukaemia study groups in the world.
Databáze:	MEDLINE
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