| Autor: |
Wiseman H; Department of Biochemistry, King's College London, UK., Smith C, Halliwell B, Cannon M, Arnstein HR, Lennard MS |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1992 Sep 14; Vol. 66 (1), pp. 61-8. |
| DOI: |
10.1016/0304-3835(92)90281-y |
| Abstrakt: |
Droloxifene (3-hydroxytamoxifen), is a triphenylethylene derivative recently developed for the treatment of breast cancer. Droloxifene was found to exhibit a membrane antioxidant ability in that it inhibited Fe(III)-ascorbate dependent lipid peroxidation in rat liver microsomes and ox-brain phospholipid liposomes. It also inhibited microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH. Droloxifene was a better inhibitor of lipid peroxidation than tamoxifen, but was less effective than 17 beta-oestradiol in the two microsomal systems and in the preformed liposomal system. When introduced into ox-brain phospholipid liposomes, droloxifene inhibited Fe(III)-ascorbate induced lipid peroxidation to approximately the same extent as similarly introduced cholesterol and tamoxifen, although to a lesser extent than 17 beta-oestradiol. This inhibition of lipid peroxidation by droloxifene may result from a membrane stabilization that could be associated in cancer cells with decreased plasma membrane fluidity. This mechanism may be related to the clinically important antiproliferative action of droloxifene on cancer cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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