| Autor: |
Romagnani S; Istituto di Medicina Interna e Immunoallergologia, Viale Morgagni 85, Firenze 50134, Italy., Parronchi P, D'Elios M, Romagnani P, Annunziato F, Menghetti M, Maggi E, Del Prete G |
| Jazyk: |
angličtina |
| Zdroj: |
The Italian journal of gastroenterology [Ital J Gastroenterol] 1996 Nov; Vol. 28 Suppl 2, pp. 11-7. |
| Abstrakt: |
The cytokine secretion profile of T cells present in the gastric antrum of Helicobacter pylori-infected patients with peptic ulcer and in the gut of patients with Crohn's disease was investigated. A type 1 T helper (Th1)-dominated response was detected in the gastric antrum of Helicobacter pylori-infected subjects with peptic ulcer by both reverse transcriptase-PCR and immunohistochemistry. By using a T-cell cloning technique, it was shown that the majority of Th 1 cells were specific for Hp antigens. A Th1 predominance, which associated with high IL-12 expression, was also found, at both clonal and immunohistochemical level, in the gut of patients with Crohn's disease. These findings suggest that the Th1/Th2 paradigm may be useful to explain the inflammatory reactions involved in the pathogenesis of some gastrointestinal disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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