| Autor: |
Mentz MB; Instituto de Ciências Básicas da Saúde, Departamento de Microbiologia, Setor de Parasitologia, Universidade Federal do Rio Grande do Sul, Brasil. mbmentz@uol.com.br, Graeff-Teixeira C |
| Jazyk: |
angličtina |
| Zdroj: |
Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2003 Jul-Aug; Vol. 45 (4), pp. 179-84. Date of Electronic Publication: 2003 Sep 17. |
| DOI: |
10.1590/s0036-46652003000400001 |
| Abstrakt: |
Abdominal and cerebral angiostrongyliasis are two important infections produced by metastrongylid worms, the former occurring in Central and South America and the later in Asia and Pacific Islands. Drug treatment is a challenge since the worms and its evolving larvae live or migrate inside vessels and efficient killing of the parasites may produce more severe lesions. Larvicidal effect of certain drugs appears to be more easily accomplished but this outcome is not useful in abdominal angiostrongyliasis since clinical manifestations appear to result from sexual maturation of the worms. We review the drug trials in murine experimental models and conclude that most of them could not be considered good candidates for treatment of human infection, except for PF1022A, pyrantel and flubendazole. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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