[The radioprotective effect of hypoxia on clonogenic cells of rat bone marrow stroma (KOE-F)].

Autor: Konopliannikov AG, Waĭnson AA, Kolesnikova AI, Zaĭtsev AV, Kal'sina SSh, Lepekhina LA
Jazyk: ruština
Zdroj: Radiobiologiia [Radiobiologiia] 1992 Sep-Oct; Vol. 32 (5), pp. 720-4.
Abstrakt: A comparative study was made on the survival rate of cell-precursors of haemopoietic stroma, that form, in a rat bone marrow culture, colonies (clones) of fibroblasts (CFU-F) after gamma-irradiation of animals in the air or in a gas hypoxic mixture, containing 8% of O2 (GHM-8). Irradiation in GHM-8 was shown to increase the survival rate of CFU-F by 1.7 times (as compared to exposure in the air) as estimated by the total number of colonies that are formed in a culture; the radioprotective effect of GHM-8 was more pronounced for CFU-F which form dense colonies: DMF for dense and loose clones was 2.4 and 1.6 respectively.
Databáze: MEDLINE