| Autor: |
Peris-Ribera JE; Department of Pharmaceutics, Faculty of Pharmacy, University of Valencia, Spain., Torres-Molina F, Garcia-Carbonell MC, Aristorena JC, Granero L |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmaceutical research [Pharm Res] 1992 Oct; Vol. 9 (10), pp. 1306-13. |
| DOI: |
10.1023/a:1015861502354 |
| Abstrakt: |
A general treatment of enterohepatic recirculation of drugs has been developed based on the fraction of drug in systemic circulation that is excreted in the bile and the fraction of drug reabsorbed from the gut that reaches systemic circulation in each enterohepatic cycle. The deduced equations make it possible to establish mathematical relationships between the areas under the blood level curves (AUC) of a drug when administered to normal and bile duct-cannulated animals and to predict the effect of enterohepatic recycling on bioavailability and clearance. The results were compared with those obtained by other authors using different approaches to enterohepatic recirculation, and some discrepancies were found in the equations describing the effect of enterohepatic recycling on AUC and bioavailability of drugs. The cause of such discrepancies and the problems associated with the prediction of hepatic extraction ratio from in vitro studies are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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