Autor:	Ablamunits VG, Kirsanova LA
Jazyk:	ruština
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1992 Jun; Vol. 113 (6), pp. 658-60.
Abstrakt:	Pseudoislets--pancreatic microfragments containing a lot of beta-cells and capable of insulin secretion in vitro-were obtained from 12 fetal calf pancreata by the use of collagenase. Morphological and functional changes of the pseudoislets were studied during culture. We found a rapid migration of beta-cells out of the pseudoislets to the bottom of plastic tissue culture plates. This process was accompanied by a significant decrease of insulin-secreting capacity of the floating microfragments. This should be taken into consideration in cases when pseudoislets are prepared for transplantation in order to avoid beta-cell loss.
Databáze:	MEDLINE
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