| Autor: |
Shelnutt S; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205., Hudzik TJ, Lattin DL, McMillan DE |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1992 Oct; Vol. 43 (2), pp. 509-11. |
| DOI: |
10.1016/0091-3057(92)90185-i |
| Abstrakt: |
The effects of cocaine and benzoylecognine ethyl ester (ethylcocaine), its metabolite found only in simultaneous users of cocaine and ethanol, were studied in rats responding for food under a multiple fixed-ratio fixed-interval schedule of food presentation. Both cocaine and ethylcocaine increased rates of responding under the fixed-interval component and decreased the quarter life. Both drugs only decreased rates of responding under the fixed-ratio component. Cocaine was approximately equipotent to ethylcocaine. Ethylcocaine may contribute to interactions between cocaine and ethanol by exerting cocaine-like effects not seen with other cocaine metabolites. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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