| Autor: |
Haigwood NL; Chiron Corporation, Emeryville, CA 94608., Misher L, Chin SM, Blair M, Planelles V, Scandella CJ, Steimer KS, Gardner MB, Yilma T, Hirsch VM, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medical primatology [J Med Primatol] 1992 Feb-May; Vol. 21 (2-3), pp. 82-90. |
| Abstrakt: |
Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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