A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus.
| Autor: | Valeski JE; IMMCO Diagnostics Inc., Buffalo, NY 14223., Kumar V, Forman AB, Beutner EH, Chorzelski TP |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1992 Aug; Vol. 27 (2 Pt 1), pp. 194-8. |
| DOI: | 10.1016/0190-9622(92)70169-g |
| Abstrakt: | Background: Antibodies to Ro(SS-A) are present in most patients with subacute cutaneous lupus erythematosus (SCLE). Patients with SCLE also have cutaneous immune deposits. However, no correlation of Ro(SS-A) antibodies with immune deposits in skin biopsy specimens has been described. Objective: The purpose of this study is to describe characteristic direct immunofluorescence (IF) findings in 32 patients and their association with serum antibodies and clinical diagnosis. Methods: Serum from patients with characteristic cutaneous direct IF findings was examined for antinuclear antibodies by indirect IF and for antibodies to ribonucleoprotein, Sm, Ro(SS-A), and La(SS-B) by gel immunodiffusion. Results: Twenty-two of 32 patients who exhibited discrete speckled IgG staining predominantly, but not exclusively, of the basal cell cytoplasm had SCLE. Ro(SS-A) antibodies were identified in 23 of 26 patients and Ro(SS-A) and/or La(SS-B) in 25 of 26 patients. Conclusion: Direct IF staining characterized by discrete speckled IgG deposits in the basal cell cytoplasm is associated with Ro(SS-A) antibodies and SCLE. |
| Databáze: | MEDLINE |
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