Successful treatment of low turnover osteoporosis resulting from prolonged reserpine therapy with intermittent calcitonin and phosphate therapy.

Autor: Armamento-Villareal RC; Division of Bone and Mineral Diseases, Washington University Medical Center, St. Louis, Missouri., Avioli LV
Jazyk: angličtina
Zdroj: Calcified tissue international [Calcif Tissue Int] 1992 Oct; Vol. 51 (4), pp. 282-4.
DOI: 10.1007/BF00334488
Abstrakt: Coherence therapy, popularly known by the acronym ADFR (Activate, Depress, Free, Repeat), was designed to increase bone mass in osteopenic patients. Accordingly, we report a case of a hypogonadal male with histologically proven low bone turnover osteoporosis and a progressive vertebral fracture syndrome, who responded favorably to ADFR treatment with the use of salmon calcitonin and inorganic phosphate. Dramatic increments in bone mass were observed during a 68-month period of therapy. Serial quantitative computerized tomography demonstrated a 146% increase from baseline in bone mineral density for the first 30 months of treatment, and dual energy radiography yielded a 36.5% increase for the subsequent 31-68 months. Furthermore, no episode of fracture occurred since coherence therapy was initiated.
Databáze: MEDLINE