Case report of a syncopal episode associated with fluoxetine.
| Autor: | McAnally LE; St. Anthony Hospital, Oklahoma City, OK 73101., Threlkeld KR, Dreyling CA |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Annals of pharmacotherapy [Ann Pharmacother] 1992 Sep; Vol. 26 (9), pp. 1090-1. |
| DOI: | 10.1177/106002809202600909 |
| Abstrakt: | Objective: To report a syncopal episode associated with fluoxetine in a young, relatively healthy man. Design: Single case report. Setting: 585-bed private hospital. Patient: A 30-year-old man with hypertension, esophageal ulcers, and syncope of recent onset. Results: Fluoxetine was started six weeks prior to the syncopal episode in this patient, and is the medication most temporally associated with the event. Because the patient had a normal neurologic examination and electroencephalogram, but an abnormal electrocardiogram on admission and one month after discharge, the syncopal episode was most likely caused by cardiovascular effects of fluoxetine. Conclusions: Fluoxetine has been reported to cause cardiac conduction abnormalities in otherwise normal individuals. Bradycardia secondary to a direct effect of fluoxetine, or to a drug interaction among fluoxetine, ranitidine, and enalapril is the most likely explanation for this patient's syncopal episode. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|