Hypersensitivity and anaphylactoid reactions to ciprofloxacin.
| Autor: | Deamer RL; Ventura County Medical Center, Office of Medical Education, CA 93003., Prichard JG, Loman GJ |
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| Jazyk: | angličtina |
| Zdroj: | The Annals of pharmacotherapy [Ann Pharmacother] 1992 Sep; Vol. 26 (9), pp. 1081-4. |
| DOI: | 10.1177/106002809202600905 |
| Abstrakt: | Objective: To report three cases of life-threatening hypersensitivity reactions to the oral administration of ciprofloxacin. Case Summary: Life-threatening hypersensitivity reactions to oral ciprofloxacin, characterized by diffuse, erythematous, nonpruritic, blanching rash, with fever and hypotension, occurred in two HIV-infected patients. One of these reactions was considered anaphylactoid. A similar hypersensitivity reaction was documented in a non-HIV-infected patient. Discussion: Premarketing clinical trials described no reports of life-threatening anaphylactoid hypersensitivity reactions to ciprofloxacin. However, postmarketing surveillance studies have documented their occurrence. Seven cases of anaphylactoid reaction to ciprofloxacin have now been documented in HIV-infected patients. Conclusions: As with trimethoprim/sulfamethoxazole, HIV-infected people treated with ciprofloxacin may be at special risk for hypersensitivity reactions. |
| Databáze: | MEDLINE |
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