| Autor: |
Kotch LE; Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill 27599., Sulik KK |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 1992 Aug; Vol. 10 (4), pp. 273-9. |
| DOI: |
10.1016/0736-5748(92)90016-s |
| Abstrakt: |
Vital staining and routine histological analyses of mouse embryos 12 h after acute maternal ethanol administration (2.9 g/kg) illustrated that selected neuronal cell populations are killed. At the time of treatment, embryos had 5-15 somite pairs, corresponding to the developmental stages occurring in humans during the fourth week of post-fertilization; i.e. when neural folds are present and neural tube fusion begins. Affected cell populations in embryos having 6-26 somite pairs (up to the stage of anterior neuropore closure) were in discrete locations in the alar and basal plates of the rhombencephalon, in the otic placode/vesicle, and in the regions of the epibranchial placodes, olfactory placodes and trigeminal ganglion. The potential basis for the vulnerability of these cell populations to ethanol-induced cell death is discussed. Our understanding of the scope of ethanol-induced CNS damage is dependent upon further defining ethanol-sensitive cell populations at all stages of CNS development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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