| Autor: |
Lieberthal W; Evans Memorial Department of Clinical Research, University Hospital, Boston, MA., LaRaia J, Valeri CR |
| Jazyk: |
angličtina |
| Zdroj: |
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology [Biomater Artif Cells Immobilization Biotechnol] 1992; Vol. 20 (2-4), pp. 663-7. |
| DOI: |
10.3109/10731199209119698 |
| Abstrakt: |
Unmodified stroma free hemoglobin (SFH) increased renal vascular resistance (RVR) from 4.0 +/- 0.2 to 6.9 +/- 0.9 mmHg/ml/min in control isolated kidneys. In kidneys obtained from rats pretreated with the thromboxane synthetase inhibitor OKY-046 RVR increased from 3.9 +/- 0.3 to 4.8 +/- 0.4 mmHg/ml/min. The percent increase in RVR was greater in response to SFH in control kidneys (67 +/- 14%) than in OKY-046 treated kidneys (23 +/- 7%)(p less than 0.05). SFH resulted in a fall in glomerular filtration rate (GFR) from 0.75 +/- 0.09 to 0.21 +/- 0.04 ml/min in control kidneys while in kidneys from OKY-046 treated rats GFR fell from 0.65 +/- 0.04 to 0.54 +/- 0.06 ml/min. The percent fall in GFR was greater in vehicle treated kidneys (69 +/- 8%) as opposed to OKY-046 treated kidneys (19 +/- 7%)(p less than 0.05). The rate of urinary thromboxane excretion measured before the addition of SFH to the perfusate was 52 pg/min in the control group and 7 pg/min in the OKY-046 treated group(p less than 0.05). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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