Multiple fractions in the treatment of head and neck cancer.

Autor: Lindup R; Radiotherapy Department, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.
Jazyk: angličtina
Zdroj: Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 1992 Sep; Vol. 4 (5), pp. 280-3.
DOI: 10.1016/s0936-6555(05)81099-4
Abstrakt: Fifty-eight cases of head and neck cancer received hyperfractionated accelerated radiotherapy, with treatment three times daily to 47.5-54 Gy over 12-20 days. A total of 69% had a complete response within 3 months, and the actuarial survival was 52% at 1 year, 41% at 2 years, 43% at 3 years and 38% at 4 years. Acute reactions were rather more pronounced (31%) and late necrosis (15%) was more than would be expected with conventional fractionation. It is suggested that multiple fractions carried out by a small centre, are feasible and will reduce hospital stay.
Databáze: MEDLINE