| Autor: |
Schmid DS; Centers for Disease Control, Division of Viral and Rickettsial Diseases, Atlanta, Georgia., Thieme ML, Ridgeway MR, Mawle AC |
| Jazyk: |
angličtina |
| Zdroj: |
Viral immunology [Viral Immunol] 1992 Winter; Vol. 5 (4), pp. 249-56. |
| DOI: |
10.1089/vim.1992.5.249 |
| Abstrakt: |
The ability of human immunodeficiency virus type-1 (HIV-1) and recombinant HIV-1 gp120 to prevent target cell lysis by herpes simplex virus type 1 (HSV-1)-specific cytotoxic T lymphocytes (CTL) was assessed by limiting dilution analysis. Live and inactivated HIV-1 as well as recombinant-derived gp120 all substantially inhibited HSV-1-specific CTL. Soluble CD4 antigen reversed the inhibition by gp120 when simultaneously added with gp120 to the assay. In addition, the monoclonal anti-CD4 antibody a-Leu3a mimicked the effects of gp120 in these experiments. These data suggest that the observed decrease in measurable CTL activity is caused by direct or steric hindrance of the CD4-class II major histocompatibility complex interaction between the effector and target cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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