| Autor: |
Janssens WJ; Department of Cardiovascular Pharmacology, Janssen Research Foundation, Beerse, Belgium. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal de pharmacie de Belgique [J Pharm Belg] 1992 Jul-Aug; Vol. 47 (4), pp. 323-7. |
| Abstrakt: |
Nebivolol is a mixture of equal amounts of two enantiomers: SR3-nebivolol (d-nebivolol) and RS3-nebivolol (l-nebivolol). SR3-nebivolol is a potent and selective beta 1-adrenergic antagonist both in vitro and in vivo. Nebivolol acutely lowers blood pressure in spontaneously hypertensive rats and induces a slight decrease in total peripheral vascular resistance and a slight increase in cardiac output in anaesthetised dogs. These hemodynamics effects cannot be explained by beta 1-adrenergic antagonism and are largely attributable to RS3-nebivolol. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
