| Autor: |
Bottje W; Department of Animal and Poultry Sciences, University of Arkansas, Fayetteville 72701., Glahn R, Beers K, Nejad H, Holmes K |
| Jazyk: |
angličtina |
| Zdroj: |
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology [Comp Biochem Physiol C Comp Pharmacol Toxicol] 1992; Vol. 101 (1), pp. 125-9. |
| DOI: |
10.1016/0742-8413(92)90209-p |
| Abstrakt: |
1. Effects of diethyl maleate (DEM) mediated glutathione (GSH) depletion on hepatic and renal cortical blood flow (perfusion), plasma GSH, and portal prostacyclin (6-ketoPGF1 alpha) and thromboxane (TxB2) were determined in anaesthetized swine. 2. Although DEM depleted hepatic GSH to 25% of control, plasma GSH increased 10-fold in comparison to controls. DEM caused a drop in blood pressure and renal cortical perfusion but had no effect on hepatic perfusion or portal 6-ketoPGF1 alpha or TxB2 levels. 3. Possibly, the unexpected rise in plasma GSH may have inhibited prostanoid synthesis, preventing any alterations in tissue perfusion that may have occurred following tissue GSH depletion. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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