Non-Hodgkin's lymphoma associated with primary Sjögren's syndrome.

Autor:	Pariente D; Service d'Immuno-Rhumatologie, Centre Gui-de-Chauliac, Hôpital Saint-Eloi, Montpellier, France., Anaya JM, Combe B, Jorgensen C, Emberger JM, Rossi JF, Sany J
Jazyk:	angličtina
Zdroj:	The European journal of medicine [Eur J Med] 1992 Oct; Vol. 1 (6), pp. 337-42.
Abstrakt:	Objectives: To evaluate the prevalence, the incidence and clinical presentation of non-Hodgkin's lymphoma associated with primary Sjögren's syndrome. Methods: Sixty-two patients with primary Sjögren's syndrome were analyzed retrospectively in an open investigation. Results: Of 62 patients with primary Sjögren's syndrome, 4 of them (6.4%) developed non-Hodgkin's lymphoma (6.9 cases per 1000 per year). All of them were women. Non-Hodgkin's lymphoma always developed after the onset of primary Sjögren's syndrome with a time interval ranging from 3 to 27 years. Pathological findings showed two diffused mixed small and large cell cleaved lymphomas and two diffused large cell cleaved lymphomas. Three cases had extra-nodular localizations. All of these 4 patients are still alive and in complete remission 2 to 8 years after the diagnosis of non-Hodgkin's lymphoma. Conclusion: This study confirms the association of non-Hodgkin's lymphoma in primary Sjögren's syndrome. These non-Hodgkin's lymphomas frequently had extra-nodal localizations. Good sensitivity to treatment, when necessary, provided good prognosis.
Databáze:	MEDLINE
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