Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.

Autor: Meijs WE; Radio-Nuclide-Centre (RNC), Free University, Amsterdam, The Netherlands., Herscheid JD, Haisma HJ, Pinedo HM
Jazyk: angličtina
Zdroj: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes [Int J Rad Appl Instrum A] 1992 Dec; Vol. 43 (12), pp. 1443-7.
DOI: 10.1016/0883-2889(92)90170-j
Abstrakt: Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.
Databáze: MEDLINE