| Autor: |
Bretti S; Ospedale San Giovanni Antica Sede, Dipartimento di Oncologia, Torino, Italy., Bonardi GM, Celano A, Comandone A, Casadio C, Marchisio U, Forconi G, Manzoni S, Bumma C |
| Jazyk: |
angličtina |
| Zdroj: |
Anticancer research [Anticancer Res] 1992 Sep-Oct; Vol. 12 (5), pp. 1459-61. |
| Abstrakt: |
A phase II trial aiming to verify the effectiveness of a regimen including carboplatin and vindesine was performed. From November 1989 to September 1990, nineteen patients with advanced small cell lung cancer entered this study. Polychemotherapy treatment included: carboplatin 400 mg/sm, on day 1 and vindesine 3 mg/sm, on days 1 and 15, repeated every 4 weeks, as an outpatient regimen. Observed toxicity was mild; myelodepression, and nausea and vomiting were the main adverse events. No objective response was obtained; 14 no changes in the disease and 4 progressions were detected. The low objective response rate observed in this study is strongly influenced by a set of unfavourable prognostic factors. The median overall survival time [32 weeks] is comparable with the results of other studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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