| Autor: |
Buckley TL; Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, Netherlands., Van de Velde MJ, Henricks PA, Engels F, Nijkamp FP |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1992 Aug 06; Vol. 218 (2-3), pp. 369-72. |
| DOI: |
10.1016/0014-2999(92)90195-a |
| Abstrakt: |
Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10(-11)-10(-9) mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4 (LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10(-11) mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4 that could have important implications in the pathogenesis of inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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