| Autor: |
Koptopoulos G; Faculty of Veterinary Medicine, Laboratory of Microbiology and Infectious Diseases, Aristotelian University, Thessaloniki, Greece., Papanastasopoulou M, Lekkas S, Skaragas G, Papadopoulos O |
| Jazyk: |
angličtina |
| Zdroj: |
Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 1992 Oct; Vol. 15 (4), pp. 235-42. |
| DOI: |
10.1016/0147-9571(92)90002-9 |
| Abstrakt: |
The influence of dexamethasone and cyclophosphamide on the goat immune system was investigated. Seven goats, with a previous contact with caprine herpesvirus type 1 (CHV-1), were used. All had been vaccinated with live Mycobacterium paratuberculosis vaccine. Six goats were injected intravenously (i.v.) with dexamethasone daily for 5 days (2.5-4 mg/kg BW per day). Three also received 25 mg/kg BW of cyclophosphamide on day 0. The seventh goat was not treated. Dexamethasone alone caused depression, slight lymphopenia and fall in tuberculin reaction. Dexamethasone plus cyclophosphamide caused a severe clinical reaction, marked leukopenia (lymphopenia and polymorphopenia), fall in tuberculin reaction and significant increase in CHV-1 neutralizing antibody titres. M. paratuberculosis antibody reaction was variable and thus difficult to be assessed. CHV-1 was not isolated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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