| Autor: |
Amvros'eva TV, Votiakov VI, Andreeva OT, Serebriakova EV, Cheshchevik AB, Samarina MP, Mishaeva NP, Zgirovskaia AA |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 1992 Jan-Feb; Vol. 37 (1), pp. 61-4. |
| Abstrakt: |
The influence of herpes simplex virus on lipid exchange and accumulation by blood vessels cells was studied. In acute herpes infection in rabbits, typical dyslipidemia characterised by a rise in the content of total cholesterol, low and very low density lipoprotein cholesterol and triglycerides in the absence of manifest changes in concentration of high density lipoprotein was detected. HSV infection of smooth muscle cell culture of human embryo aorta was accompanied by increased accumulation of free lipids in the cells. The use of antiherpetic preparations during the infection led to correction of the lipid spectrum of the infected animals and was accompanied by normalization of intracellular lipid contents. A possible pathogenetic role of HSV in atherogenesis which may be connected with at least two processes: the development of lipidemic disturbances and formation of pathologic lipid depot in the arterial wall, is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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