| Autor: |
Norgren RB Jr; Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, OH 45267-0521., McLean JH, Bubel HC, Wander A, Bernstein DI, Lehman MN |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research bulletin [Brain Res Bull] 1992 Mar; Vol. 28 (3), pp. 393-9. |
| DOI: |
10.1016/0361-9230(92)90038-y |
| Abstrakt: |
The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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