| Autor: |
Bilello JA; University of Maryland Cancer Center, Baltimore, Maryland 21201., Kort JJ, MacAuley C, Fredrickson TN, Yetter RA, Eiseman JL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of acquired immune deficiency syndromes [J Acquir Immune Defic Syndr (1988)] 1992; Vol. 5 (6), pp. 571-6. |
| Abstrakt: |
LP-BM5 MuLV infection of monocyte-macrophages (MM cells) and the ability of MM cells infected with this murine oncornavirus complex to transmit murine acquired immune deficiency syndrome (MAIDS) were assessed. Adherent cells expressing Mac-1 antigen (Mac-1+) were isolated from the peritoneum of infected C57BL/6 mice at weekly intervals postinoculation. A small percentage of MM cells was infected by 7 days after inoculation with LP-BM5 MuLV and virus production could be detected in MM cells throughout the course of disease. MAIDS could be induced in naive C57BL/6 mice by i.p. injection of 0.5-3 x 10(5) MM cells derived from infected mice as early as 8 weeks postinfection. When 3 x 10(5) cells (300 infectious centers) were injected, the progression of disease was similar to that seen after inoculation with a known virus pool (log10 5.78 XC pfu/ml). Treatment with zidovudine (ZDV) at 1 mg/ml in drinking water delayed disease progression if started 24 h prior to inoculation of MM cells and given continuously. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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