| Autor: |
Brody BA; Department of Microbiology, University of Alabama, Birmingham 35294., Hunter E, Kluge JD, Lasarow R, Gardner M, Marx PA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 1992 Jun; Vol. 66 (6), pp. 3950-4. |
| DOI: |
10.1128/JVI.66.6.3950-3954.1992 |
| Abstrakt: |
Rhesus macaques were immunized with live vaccinia virus recombinants expressing the envelope glycoproteins (gp70 and gp22) of simian type D retrovirus (SRV), serotype 1 or 3. All of the animals immunized with either the SRV-1 env or the SRV-3 env vaccinia virus recombinant developed neutralizing antibodies against the homologous SRV. In addition, both groups developed cross-reactive antibodies and were protected against an intravenous live-virus challenge with SRV-1. The four control animals immunized with a vaccinia virus recombinant expressing the G protein of respiratory syncytial virus were not protected against the same SRV-1 challenge. Although SRV-1 and SRV-3 immune sera showed cross-neutralization, they failed to neutralize a separate, more distantly related serotype, SRV-2, in an in vitro assay. These findings are consistent with the known degree of serologic and genetic relatedness of these three SRV strains. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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