| Autor: |
Seishima M; Department of Dermatology, Gifu University School of Medicine, Japan., Nagao S, Kuwahara M, Mori S, Nozawa Y |
| Jazyk: |
angličtina |
| Zdroj: |
The British journal of dermatology [Br J Dermatol] 1992 Mar; Vol. 126 (3), pp. 231-5. |
| DOI: |
10.1111/j.1365-2133.1992.tb00650.x |
| Abstrakt: |
Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP-phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated level of calmodulin may play a role in the pathogenesis of PSS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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