[The energy metabolism of the liver under the action on the body of different durations of hypokinesia].

Autor: Gritsiuk AI, Danilova IG, Segal' NK
Jazyk: ruština
Zdroj: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine [Aviakosm Ekolog Med] 1992 Sep-Dec; Vol. 26 (5-6), pp. 35-9.
Abstrakt: Studies of tissue respiration and oxidative phosphorylation of homogenates in the liver of white rats indicated that the 3-day hypokinesia is associated with a decreased rate of endogenic respiration and an increased amythal-resistant respiration. On the 10th day, there occurs a sharp increase of the oxidation rate of the endo- and exogenic substrates and the separation of oxidative phosphorylation takes place. During 30-day immobilization, the homogenate respiratory activity again decreases while on the 70-140th days of an exposure the oxidation rate of endo- and exogenic substrates increases with an increased effect of endogenic succinate on the hepatocyte energy metabolism. The possible mechanism disturbances in the liver of immobilized animals are discussed.
Databáze: MEDLINE