| Autor: |
Singhasivanon V; Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Chongsuphajaisiddhi T, Sabcharoen A, Attanath P, Webster HK, Wernsdorfer WH, Sheth UK, Djaja Lika I |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 1992 Oct-Dec; Vol. 17 (4), pp. 275-9. |
| DOI: |
10.1007/BF03190160 |
| Abstrakt: |
The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 250 mg+sulfadoxine 500 mg+pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight. All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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