| Autor: |
Ottolini M; Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. mottolini@usuhs.mil, Blanco J, Porter D, Peterson L, Curtis S, Prince G |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric pulmonology [Pediatr Pulmonol] 2003 Oct; Vol. 36 (4), pp. 290-4. |
| DOI: |
10.1002/ppul.10320 |
| Abstrakt: |
The cotton rat was evaluated as a model for anti-inflammatory and antiviral influenza therapy. Beginning 3 days after intranasal infection with 10(7) tissue culture infectious doses-50% (TCID)(50) of an H3N2 human influenza, animals were treated topically via intranasal lavage with a range of doses of triamcinolone acetonide (1, 4, or 16 mg/kg), alone or in combination with a neuraminidase inhibitor or anti-influenza convalescent serum. Pulmonary histopathologic changes were dramatically decreased in animals treated with 4 or 16 mg/kg of triamcinolone, with little additional benefit from addition of a neuraminidase inhibitor or topical serum, agents which were much less effective when used alone. A high degree of suppression of IFN-gamma levels was observed in all combinations where 4 or 16 mg/kg of triamcinolone were used. Viral replication was not prolonged by corticosteroid therapy. Tissue damage during influenza infection may be greatly reduced by combination antiviral and anti-inflammatory therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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