| Autor: |
Pal'mina NP; N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow., Gaintseva VD, Burlakova YB |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2003 Jan; Vol. 135 Suppl 7, pp. 52-3. |
| DOI: |
10.1023/a:1024770411332 |
| Abstrakt: |
Synthetic antioxidant potassium phenosan in ultralow doses administrated in combination with antitumor antibiotic adriamycin in a therapeutic dose (8 mg/kg) markedly prolonged the mean life span of tumor-bearing animals compared to adriamycin monotherapy. This effect depended on the dose of antioxidant and was maximum at phenosan concentrations of 10(-17) and 10(-15) M. Potassium phenosan in these concentrations not only increased the mean life span, but also determined survival of 10-20% animals (as differentiated from adriamycin monotherapy). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink