Solid phase extraction of phencyclidine from urine followed by capillary gas chromatography/mass spectrometry.

Autor: Stevenson CC; U.S. Army Forensic Toxicology Drug Testing Lab, Ft. Meade, MD 20755., Cibull DL, Platoff GE Jr, Bush DM, Gere JA
Jazyk: angličtina
Zdroj: Journal of analytical toxicology [J Anal Toxicol] 1992 Sep-Oct; Vol. 16 (5), pp. 337-9.
DOI: 10.1093/jat/16.5.337
Abstrakt: This communication describes a method for the solid phase extraction of phencyclidine (PCP) from urine, followed by GC/MS analysis. The method is linear over the range 5-1000 ng/mL and consistently produces cleaner chromatograms than can be obtained by liquid-liquid extraction. The limits of detection and quantitation are 0.47 and 1.38 ng/mL, respectively. Extraction efficiency, or recovery, was found to be 100.8 +/- 6.5%, and the between-run precision was 3.5% (25 ng/mL, n = 51). This solid phase method for extraction of PCP from urine has several advantages over liquid-liquid extraction for laboratories of any size.
Databáze: MEDLINE