Is obesity an inflammatory disease?

Autor: Ramos EJ; Department of Surgery, Management Information and Decision, Clinical Molecular Medicine, SUNY Upstate Medical University, Syracuse University, Syracuse, NY, USA., Xu Y, Romanova I, Middleton F, Chen C, Quinn R, Inui A, Das U, Meguid MM
Jazyk: angličtina
Zdroj: Surgery [Surgery] 2003 Aug; Vol. 134 (2), pp. 329-35.
DOI: 10.1067/msy.2003.267
Abstrakt: Background: Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), markers of inflammation closely associated with diabetes, hypertension, and stroke.
Hypothesis: Obesity is a low-grade inflammatory disease, and Roux-en-Y gastric bypass (RYGB) reduces biochemical markers of inflammation and modifies gene expression in hypothalamic food intake/energy-related nuclei and subcutaneous abdominal fat (SAF).
Methods: Obesity was induced in 24 3-week-old Sprague Dawley pups fed a high-energy diet (HED). Three groups (n = 8/group) were studied: RYGB, sham-operated pair-fed, and sham-operated ad libitum HED. Controls were nonobese rats fed chow (n = 6). Rats were killed 10 days after operation, and blood was collected to measure corticosterone and SAF and mesenteric fat to measure IL-6, TNF-alpha, and corticosterone. Total mRNA from arcuate nucleus and SAF purified for gene expression profiling. Data were analyzed with analysis of variance, Mann-Whitney test, and t test.
Results: Before operation, the body weight of the obese groups was 493 +/- 7 g and control = 394 +/- 12g. The 10-day postoperative weight was RYGB = 417 +/- 21 g, pair-fed = 436 +/- 14 g, and ad libitum HED = 484 +/- 15 g. Mesenteric and SAF weight decreased in RYGB. Mesenteric/SAF ratio of IL-6, TNF-alpha, corticosterone, and gene profiling showed decrease of inflammation after RYGB.
Conclusions: Gastric bypass reduces biochemical markers of inflammation, suggesting that obesity is an inflammatory condition.
Databáze: MEDLINE
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