| Autor: |
Alshimmiri MM; Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, 13110, Kuwait. majed@hsc.kuniv.edu.kw, Al-Saleh EA, Al-Harmi JA, AlSalili MB, Adwani AA, Ibrahim ME |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2003 Aug; Vol. 268 (3), pp. 181-3. Date of Electronic Publication: 2002 Sep 07. |
| DOI: |
10.1007/s00404-002-0357-9 |
| Abstrakt: |
This study evaluates the outcome of unruptured ectopic pregnancies treated with single-dose intramuscular methotrexate injection. There were 77 women with unruptured non-laparoscopically diagnosed ectopic pregnancies who were prospectively followed after receiving a single dose of 50 mg/m2 intramuscular methotrexate. Diagnosis required transvaginal ultrasound and serial quantification of beta subunit of human chorionic gonadotropin (betahCG). A repeat dose was given if the weekly drop of betahCG was less than 30%. Therapy was considered successful if complete resolution of betahCG to a level below 25 IU/L was achieved without surgical intervention. Treatment in 73 (95%) cases was successful. The mean pre-treatment level of betahCG was 2592 +/- 3771 IU/L (177-15000 IU/L), the mean diameter of ectopic mass was 2.4 +/- 1.0 cm (1.7-3.5 cm). The average resolution period was 3.2 +/- 1.0 weeks (1-6 weeks) and this significantly correlated with the pre-treatment betahCG level. With strict criteria of inclusion and follow-up, single-dose intramuscular methotrexate is a successful method for the treatment of selected cases of ectopic pregnancy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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