[Complications of intraoperative radiotherapy and adjuvant chemotherapy in patients with lung cancer].

Autor: Zyrianov BN; Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk., Zav'ialov AA, Miller SV, Khodkevich BS, Kolomiets SA, Evtushenko VA, Cheremisina OV, Rudyk IuV, Tropin SV
Jazyk: ruština
Zdroj: Voprosy onkologii [Vopr Onkol] 2003; Vol. 49 (3), pp. 370-2.
Abstrakt: A high single dose of radiation can be delivered precisely to tumor or regional metastasis area by means of intraoperative radiation therapy (IORT). A program of combined treatment including radical IORT, postoperative distant gamma-therapy and adjuvant polychemotherapy with cisplatin and etoposide has been developed at the Center. Treatment was given to 43 patients with stage III lung cancer. Complications were reported in 23.3 +/- 6.0%. Prophylactic methods have been worked out to minimize IORT--related postoperative complications. The postoperative lethality rate was 2.3 +/- 1.4%. No program-related hazards have been observed. Complications from adjuvant polychemotherapy were moderate.
Databáze: MEDLINE