| Autor: |
Garibova TL; Laboratory of Psychopharmacology, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia., Galaeva IP, Voronina TA, Kraĭneva VA, Kapitsa IG, Kirichenko SV, Makarenko AN, Mirzoian GR, Kuznetsova EA |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2003 May-Jun; Vol. 66 (3), pp. 13-6. |
| Abstrakt: |
The effect of the new nootropic drug nooglutyl, a positive modulator of AMPA-subtype glutamatergic receptors, was studied in rats with a model hemorrhagic stroke (HS)--posttraumatic hematoma induced by cerebral tissue destruction in the capsule interna region. Single intraperitoneal injections of nooglutyl (10 and 20 mg/kg) 3-4 h after operation decreased the HS-induced neurological deficiency, restored the coordination of movements, improved the passive avoidance reaction retrieval, and prevented the loss of experimental animals. The results show evidence of a pronounced neuroprotector action of nooglutyl in rats with the HS model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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