[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)].

Autor: Shalimov SA, Trokhimenko EP, Dziublik IV, Keĭsevich LV, Volchenskova II, Kogut GI, Glukhen'kaia GT
Jazyk: ruština
Zdroj: Likars'ka sprava [Lik Sprava] 1992 Nov-Dec (11-12), pp. 114-7.
Abstrakt: The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.
Databáze: MEDLINE