Impact of diabetes on cognitive function among older Latinos: a population-based cohort study.

Autor: Wu JH; University of Michigan, School of Public Health, Department of Epidemiology, 611 Church St., Ann Arbor, MI 48104, USA., Haan MN, Liang J, Ghosh D, Gonzalez HM, Herman WH
Jazyk: angličtina
Zdroj: Journal of clinical epidemiology [J Clin Epidemiol] 2003 Jul; Vol. 56 (7), pp. 686-93.
DOI: 10.1016/s0895-4356(03)00077-5
Abstrakt: Background and Objectives: Type 2 diabetes, which is highly prevalent in older Mexican Americans, may influence cognitive functioning. We examined the association of diabetes with decline in global cognitive function and memory function over a 2-year period.
Methods: Study subjects were derived from an existing cohort of Latinos aged 60 and over in the SALSA project (n=1,789). Statistical analysis was conducted using logistic regression and a generalized estimating equation (GEE).
Results: Logistic regression analysis indicated that baseline diabetes was a significant predictor of major cognitive impairment in Modified Mini Mental State Exam (3MSE) (OR=1.68, 95% CI=1.21, 2.34) and word-list test (OR=1.31, 95% CI=0.99, 1.75). GEE analysis showed that there was no significant difference between diabetic and nondiabetic subjects in change of cognitive scores over 2 years (3MSE, mean=-0.58, 95% CI=-1.48, 0.32; word-list test, mean=-0.10, 95% CI=-0.32, 0.11).
Conclusions: More diabetic complications were associated with major cognitive decline among diabetic subjects. Research on long-term impact of treatment for type 2 diabetes is warranted.
Databáze: MEDLINE
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