Antibodies to dopamine as neuromodulators of behavioral responses of mice of different genotypes.

Autor: Evseev VA; Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow., Mikovskaya OI, Vetrilé LA, Trekova NA, Basharova LA, Khlopushina TG, Gruden' MA
Jazyk: angličtina
Zdroj: Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2003 Jun; Vol. 33 (5), pp. 507-12.
DOI: 10.1023/a:1023471402939
Abstrakt: The possibility of long-term changes in the innate characteristics of the behavior of mice of different genotypes (C57Bl/6 and BALB/c) after active immunization with dopamine-BSA conjugates was studied. These experiments revealed significant differences in the effects of anti-dopamine antibody on behavioral responses in an open field and neurotransmitter contents of brain structures in mice of different lines. Immunization with the dopamine-protein conjugate led to increases in the functional activity of the corresponding brain receptors, to different extents in mice of different lines.
Databáze: MEDLINE