| Autor: |
Kuipers S; Eijkman-Winkler Centre for Microbiology, Infectious Diseases and Inflammation, University Medical Centre, Utrecht, The Netherlands., Aerts PC, Cluysenaer OJ, Bartelink AK, Ezekowitz RA, Bax WA, Salimans M, Vandyk H |
| Jazyk: |
angličtina |
| Zdroj: |
Advances in experimental medicine and biology [Adv Exp Med Biol] 2003; Vol. 531, pp. 351-5. |
| DOI: |
10.1007/978-1-4615-0059-9_29 |
| Abstrakt: |
A case of familial meningococcal meningitis is described, which involved a 18-year old boy, his mother, and his grandfather, from who all three suffered from meningococcal disease at about similar age (17-19 y), albeit with one or two generations in between. By studying the genetic variants of MBL, we found out that all three family members described carried the B, D variant mbl genes instead of the homozygous mbl A, A trait. Serum MBL levels within the family varied from <0.15 microgs per ml (for the B, D variant) up to 7.0 microgs per ml with 1.67 microgs per ml as mean serum level of a control population (n = 216); in the normal population, also incidental cases with serum levels of up to 16 (!) microg-equivalents per ml were observed, which occurred predominantly in elderly people and which are most likely to be explained by the acute-phase reactant behavior of MBL protein. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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